OMNISENSE 7000S/8000S

Clinical Summary #5

  Discrimination of Proximal Hip Fracture by  
Quantitative Ultrasound Measurement at the Radius

M. Weiss, A. Ben-Shlomo, P. Hagag, and S. Ish-Shalom 
Osteoporosis Int. (2000) 11:411-416

Omnisense demonstrates its ability to assess hip fracture risk of subjects by speed of sound measurements at the radius.

Introduction
Osteoporosis is a disease that culminates with fragility fractures and imposes a major burden on health care costs. In dealing with this worldwide condition, it is prudent to use a reliable, non-expensive, portable diagnostic device that does not use ionizing radiation and is capable of measuring bone properties at several sites. Sunlight Omnisense 7000S, a quantitative ultrasound device which measures the speed of sound (SOS) along the bone at multiple skeletal sites, provides such a solution.

Study Design
The study was designed to evaluate the ability of the Omnisense to assess fracture risk. Three groups of women were recruited for this cross-sectional study:

• Elderly women with osteoporotic proximal hip fractures
• Elderly women without any evidence of osteoporotic fractures
• Young, healthy women 

Speed of Sound measurements were performed at the distal 1/3 of the radius.

Results
SOS was found to be significantly lower in the fractured group than in the non-fractured group. Hip fracture subjects had a mean speed of sound (SOS) of 3861±149 m/s, while non-fracture subjects had a mean SOS of 3966±145 m/s. Thus, there was a difference of 105 m/s between the two groups (t-test p<0.0001).  A low SOS is an indication of unhealthy bone and increased fracture risk (ROC curves indicate an AUC of 0.79 (95% CI, 0.73 - 0.86)). Assessment of fracture risk can presented by odds ratio (OR). In this study, OR was 2.16 (95% CI, 1.46 - 3.19). This analysis shows that for every 100 m/s decrease in SOS the odds of fracture increase by about 50% and that for every decrease of 162 m/s in SOS the odds of fracture double.

T-Score Discrimination by Age

Conclusion
SOS, as measured by the Omnisense, can be considered an important factor in aiding the physician when diagnosing a patient for osteoporosis and determining the patient's risk of fracture.

Osteoporosis
Bone Densitometry
''For better prevention, detection, diagnosis,
and treatments of Osteoporosis''
278 S. Lincoln St., Minster, OH 45865
Phone: 1-888-999-4774
Fax: 1-419-628-4005
Email: info@bonedensitometry.com

"As president, I have committed my company to providing medical facilities with "state-of-the-art" bone densitometry equipment to help them do a better job with preventing, testing for, screening for, detecting, diagnosing, and treating Osteoporosis which ravage so many women and men. Our diagnostic equipment will speed up the prevention, detection, diagnosis, and treatment of Osteoporosis and osteoporotic bone disorders in men and women. The key to preventing Osteoporosis in women and men is early detection, diagnosis, and treatment. This means measuring, testing, screening, detecting, and diagnosing low bone mass in women and men early in their lifetimes so that effective treatment can stop the Osteoporosis dead in its tracks." Together, we can help protect families from this terrible disease.

Sincerely,
Mark Piening

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